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Heart diseases is also known as cardiovascular disease, It includes stroke, hypertensive heart disease, aortic aneurysms, cardiomyopathy, atrial fibrillation, congenital heart disease, endocarditis and peripheral artery disease.
These may be caused by high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself.
Heart diseases are sometimes fatal and can be present by birth. Heart diseases from birth are termed as congenital heart disease.Congenital heart defects change the normal flow of blood through the heart.
Journals related to Heart Diseases Journal of Clinical & Experimental Cardiology, Angiology: Open Access, Arrhythmia: Open Access, Journal of Cardiovascular Diseases & Diagnosis, Arteriosclerosis, Thrombosis, and Vascular Biology, Stroke, Journal of American Heart Association, AHA Journals.
Yosef Yarden Classically, the 3a??untranslated region (3a??UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3a??UTR alone, without all other elements in mRNA such as 5a??UTR and coding region. The importance of independent 3a??UTR RNA (referred as I3a??UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3a??UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3a??UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3a??UTR were important for its tumor suppression activity. Then, the C/EBP 3a??UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3a??UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3a??UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990a??s to 2000a??s, world scientists found several 3a??UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3a??UTR regions, although the existence of their transcribed products as independent 3a??UTR RNAs is still to be confirmed. Our studies indicate that the independent 3a??UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole. PPT Version | PDF Version